Heart Biopsy Treatment in India Get ready to connect with the best cardiologists across the globe on GoMedii. Learn what a cardiac biopsy really is here. A cardiac biopsy involves taking small samples of heart muscle to examine under a microscope. It is usually done to look for rejection of the new heart after a heart transplant. It is also done to diagnose the cause of newly found heart failure or to determine the cause of specific heart muscle problems where all other tests cannot make a clear diagnosis. It is usually a one-day procedure. About Heart biopsy is currently the only reliable means of diagnosing cardiac rejection. It is performed at regular intervals after surgery, sometimes when rejection is suspected, and to assess the adequacy of antirejection therapy. In adults and older children, routine heart biopsies are performed approximately every week for the first four weeks after the operation and then with less frequency depending on your course. After six months, most patients can have routine biopsies every three months. The need for surveillance biopsies on a regular basis is uncertain.